Agomelatine

Information About Agomelatine

Uses of Agomelatine

Agomelatine is commonly used to treat depression.

How Agomelatine Works

Agomelatine is a psychoanaleptics. It works by binding to melatonergic agonists to re-synchronize disrupted circadian rhythms. It also works as an antagonist to increase the release of noradrenaline and dopamine

Side Effects of Agomelatine

Headache, Nausea, Dizziness

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Agomelatine Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Agomelatine. Taking Agomelatine with alcohol may have affect the liver function.

Pregnancy Not Safe

There are limited data available on the effect of Agomelatine on human pregnancy. Therefore, it is considered safe to avoid the use of this medication altogether during pregnancy.

Lactation Limited Data

Available data indicate the excretion of Agomelatine in the mother's milk. However, data available does not explain the risk implicated by the presence of Agomelatine in milk upon the infant consuming it.

Driving Generally Safe

Agomelatine has little to no effect on a patient's ability to drive. However, side effects like dizziness and somnolence need to be considered.

Kidney Use With Care

Agomelatine use in patients with renal impairment has shown no dose adjustment needed. However, further data on this is very limited. Therefore, it is advised to be cautious when prescribing this drug.

Liver High Risk

Agomelatine is contraindicated in patients with liver impairment.