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Alfacalcidol is commonly used to treat hypocalcaemia, hypoparathyroidism, hypophophataemia, renal osteodystrophy and rickets/osteomalacia
Alfacalcidol is a precursor to calcitriol. It undergoes 25-hydroxylation in the liver to become the active calcitriol (1, 25-dihydroxyvitamin D3) which enables calcium absorption from the intestine and renal as well as from bone resorption.
No appetite, Nausea, Vomiting, Increase urination, Sweating, Headache, Thirst, Skin rash, Vertigo
Consumption of alcohol with Alfacalcidol is thought to be safe and does not affect the absorption of Alfacalcidol based on the clinical data.
Animal studies have shown reproductive toxicity in higher dose while there is only limited data regarding the safety profile of Alfacalcidol during human pregnancy. It is therefore should be avoided to be used during pregnancy or use with caution by doctor's advice.
It is not fully known how much the active calcitrol will be in the breastmilk. The presence of this active metabolites may disturb the normal calcium metabolism of an infant. Hence, it is advisable to closely monitor the infant's health following the mother's intake of Alfacalcidol.
Generally, consumption of Alfacalcidol does not affect concentration or the ability to drive. If side effects such as headache and vertigo develop, it is not recommended for the user to drive afterwards.
Alfacalcidol is regularly used in patients with renal impairment. Caution should be taken to avoid hyperphosphataemia either by taking together with phosphate binders or monitoring closely level of phosphate in the blood.
Alfacalcidol is noted to be safe and may only cause slight increase in liver enzymes level in people with hepatic impairment.