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Clomipramine is commonly used to treat anxiety disorder such as panic disorder and phobia, depression, obsessive compulsive disorder, adjunct to cataplexy associated with narcolepsy.
Clomipramine is a serotonin reuptake inhibitor in the brain with significant antagonism at cholinergic and alpha�1-receptors. It is also a weak antagonist for dopamine receptor.
Increased appetite, Restlessness, Dizziness, Tremor, Headache, Confusional state and disorientation, Hallucinations (particularly in elderly patients and patients with Parkinson's disease), Difficulty sleeping (insomnia), Blurred vision, Palpitation, Orthostatic hypotension
It is unsafe to consume alcohol with Clomipramine as when taking together, there are higher risk of experiencing side effects such as headache, dizziness, somnolence, fainting, and/or changes in pulse or heart rate.
Clomipramine may be unsafe to be used during pregnancy. No information about fetal abnormality when taking clomipramine during pregnancy. Nevertheless, neonates may develop dyspnoea, lethargy, irritability, hypo or hypertension during the first few days post delivery upon taking Clomipramine up until delivery.
Clomipramine should be discontinued during lactation as it is proven to be excreted into human milk in small quantities.
It is unsafe to take Clomipramine and drive as it may influence general attention during driving due to side effects such as headache, dizziness, somnolence, fainting, and/or changes in pulse or heart rate.
Clomipramine should be given with caution in patients with kidney disease. Dosage adjustment may be needed. Thus, please consult your doctor.
Clomipramine should be given with caution in patients with liver disease and dose titration of Clomipramine may be needed along with liver function monitoring.