Domperidone

Information About Domperidone

Uses of Domperidone

Domperidone is commonly used to treat gastrointestinal symptoms such as heartburn, indigestion, nausea, and vomiting.

How Domperidone Works

Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier.

Side Effects of Domperidone

Diarrhea, Dry mouth, Amenorrhea, Breast pain, Convulsions, Rash, Stomach cramps, Anxiety, Headache, Urinary retention

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Domperidone Related Warnings

Alcohol Safe

There could be a possible interaction between domperidone and alcohol. Otherwise, it is fairly safe to consume alcohol while on domperidone.

Pregnancy Not Safe

There is limited data on human study regarding the use of domperidone among pregnant women. Animal studies have demonstrated reproductive toxicity when it is used at a high, toxic dose. The risk for the fetus in humans is still uncertain therefore it is recommended to only use domperidone if the benefits outweigh the potential risk to the fetus.

Lactation Limited Data

Generally, domperidone is excreted in breast milk and even though the infant only receives a small percentage of Domperidone's dose, cardiac effects remained unknown. To discontinue breastfeeding or stop taking domperidone depends on the therapeutic benefits to mother or benefits of breastfeeding for the infant.

Driving Generally Safe

Domperidone usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Domperidone should be used with caution in patients with severe renal impairment as the elimination half-life is prolonged. Dose adjustment is also required and patients on prolonged therapy need to be monitored closely and regularly.

Liver Limited Data

In mild liver impairment, dose adjustment is not required however, domperidone must be avoided in moderate to severe liver impairment.