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Letrozole is commonly used to treat breast cancer, infertility, infertility due to anovulation
Letrozole is a non-steroidal aromatase enzyme inhibitor. It significantly reduces serum oestrogen concentration by competitively bind to an enzyme, blocking the conversion of androstenedione and testosterone into oestriol and oestradiol respectively.
Increased cholesterol level, Increased/decreased appetite, Difficulty sleeping (insomnia), Depression, Dizziness, Headache, Palpitations , Hot flushes , Hypertension, Perfused sweating
It is safe to consume alcohol with Letrozole as there is no known drug interactions.
Letrozole is contraindicated in pregnancy as there are reported cases of congenital malformations such as ambiguous genitalia and labial fusion.
There is no information regarding the presence of Letrozole and its metabolites in human milk. Therefore, the risk of adverse effects cannot be excluded and it is not recommended to use the medication during the nursing period.
Letrozole may cause side effects such as dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.
No dose adjustment of Letrozole is needed in mild to moderate kidney disease. There is no information regarding dose titration in severe kidney disease. Therefore, Letrozole should be used with caution in severe kidney disease. Please consult your doctor.
Letrozole should be used with caution in patients with severe liver disease as dose adjustment of Letrozole may be needed. However, in mild to moderate liver disease, no dose adjustment is required. Please consult your doctor.
