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Mefenamic acid is commonly used in the treatment of arthralgia joint pain, muscle pain, osteoarthritis, pain during menstruation, dental pain, headache, menorrhagia, post-operative pain and rheumatoid arthritis
Mefenamic acid is a Nonsteroidal anti-inflammatory drug (NSAID) that reversibly blocks the cyclooxygenase-1 and -2 (COX-1 and -2) enzyme, causing a reduction in synthesis of prostaglandin precursors thereby exerting its analgesic, antipyretic and anti-inflammatory effect.
Difficulty sleeping (insomnia), Fatigue, Headache, Diarrhea, Nausea, Vomiting, Abdominal pain, Flatulence, Constipation, Dyspepsia, Heartburn, Gastritis, Nervousness, Nnsomnia, Confusion, Depression, Pruritus, Urticaria, Rash, Tinnitus, Fuid retention, Anaemia, Hyperkalaemia, High blood pressure.
GI bleeding, ulceration or perforation has been reported with NSAIDs at any time during treatment. Consuming alchol while on Mefenamic acid are added risk factors.
NSAIDs should not be used during the first two trimesters of pregnancy or labour unless the potential benefit to the patient outweighs the potential risk to the foetus. Mefenamic acid is contraindicated during 3rd trimester of pregnancy due to risk of closure of the ductus arteriosus, delayed onset of labour and risk of bleeding to mother and child.
Mefenamic acid is probably unsafe to use during lactation as it is excreted into human breast milk and is transmitted to the child.
Do not drive unless you are feeling well. Mefenamic acid may cause side effects such as dizziness, drowsiness, tiredness or visual disturbances, all of which could affect the ability to concentrate and drive.
Mefenamic acid's mechanism of action which reduces prostaglandin synthesis can cause renal failure. Hence, it should be used with caution in patients with kidney impairment, in elderly patients and diuretics users. Please consult your doctor before usage.
Mefenamic acid should be used with caution in patients with liver disorder because it is the main site of metabolism. Liver function test should be monitored. Please consult your doctor before usage
