Megestrol

Information About Megestrol

Uses of Megestrol

Megestrol is commonly used to treat breast cancer, endometrial cancer and to overcome severe weight loss and loss of appetite in patients with hiv.

How Megestrol Works

Megestrol is a synthetic progestogen used as an antineoplastic and appetite stimulant. Through its antiestrogenic properties inhibition, it is indicated for certain hormone- dependent neoplasms. It has glucocorticoid effect but a very slight mineralocorticoid effect.

Side Effects of Megestrol

Weight gain, Constipation, Urinary frequency, Cushing's syndrome, Cushingoid, Increased blood sugar, Increased appetite, Mood lability, Hot flush, Increased blood pressure, Difficulty breathing, Rash, Menorrhagia, Erectile dysfunction, Tumor flare

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Megestrol Related Warnings

Alcohol Safe

Consuming alcohol in moderation doesn't cause the disturbance to pharmacokinetics of Megestrol. However, please consult your doctor before using it.

Pregnancy Not Safe - High Risk

Megestrol in oral suspension form may be unsafe to use during pregnancy due to proven foetal abnormalities in animal and human studies. Megestrol in oral tablet form may have shown adverse effects on the fetus, however, benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.

Lactation Not Advisable

Due to potential adverse effects of Megestrol, it is probably not safe to use during lactation. Please consult your doctor before using it.

Driving Generally Safe

Megestrol may cause minimal to no side effects which could affect your ability to concentrate and drive.

Kidney Use With Care

Megestrol should be used with caution in patients with kidney disease. Dose adjustment of Megestrol may be needed. Please consult your doctor before using it.

Liver Use With Care

Megestrol should be used with caution in patients with kidney disease. Dose adjustment of Megestrol may be needed. Please consult your doctor before using it.