Paricalcitol

Information About Paricalcitol

Uses of Paricalcitol

Paricalcitol is commonly used to treat and prevent secondary hyperparathyroidism due to chronic kidney disease.

How Paricalcitol Works

Paricalcitol is a synthetic vitamin D analogue which activates vitamin D receptors in the various organs. The parathyroid hormone (PTH) level is reduced by inhibiting PTH synthesis and secretion and thus improves calcium and phosphate level in metabolic bone disease.

Side Effects of Paricalcitol

Hypercalcaemia, hypercalciuria and hyperphosphatemia, Dizziness, Palpitations, Dyspepsia, Taste disturbance, Dry mouth, Nausea, Vomiting, Constipation, Diarrhea, Abdominal discomfort, Increased blood creatinine, Breast tenderness, Hypoparathyroidism, Musculoskeletal pain, Rash, Malaise, Pyrexia.

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Paricalcitol Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Paricalcitol especially in individuals with alcoholism. Please consult your doctor before using it.

Pregnancy Not Safe

Paricalcitol may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.

Lactation Limited Data

Paricalcitol is excreted into breast milk of mammals but the excretion into human breast milk and its adverse effect on the feeding baby is inconclusive. The decision to discontinue breastfeeding or withhold medication is to be made after consulting your doctor.

Driving Generally Safe

Paricalcitol cause minimal to no side effects which could affect your ability to concentrate and drive

Kidney Use With Care

Paricalcitol should be used with caution in patients with mild to moderate kidney disease. Dose adjustment of Paricalcitol may be needed. Please consult your doctor before using it. Use of Paricalcitol in patients with severe kidney disease is unknown.

Liver Limited Data

Paricalcitol should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Paricalcitol is not needed. Please consult your doctor before using it. Use of Paricalcitol in patients with severe kidney disease is unknown.