Rosuvastatin

Information About Rosuvastatin

Uses of Rosuvastatin

Rosuvastatin is commonly used in the treatment of high cholesterol, high ldl levels, high triglycerides, and low hdl (good cholesterol).

How Rosuvastatin Works

Rosuvastatin inhibits HMG-CoA reductase which is responsible for cholesterol synthesis. It increases the number of hepatic LDL receptors on the cell surface, reinforcing uptake and catabolism of LDL. Besides, it also reduces the amount of apolipoprotein B, triglycerides and increases HDL levels.

Side Effects of Rosuvastatin

Headache, Dizziness, Nausea and vomiting, Abdominal pain, Chest pain, Peripheral oedema, Muscle pain, Rash, Abnormal liver function

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Rosuvastatin Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Rosuvastatin because it may worsen the side effects such as headache, dizziness, nausea and further impair the liver function.

Pregnancy Not Safe - High Risk

Rosuvastatin is proven unsafe to use during pregnancy. Both animal and human studies have shown fetal abnormalities or fetal risk based on the adverse effects of Rosuvastatin in pregnant women.

Lactation Not Advisable

Rosuvastatin is unsafe to use during lactation. No reports explaining the use of rosuvastatin in human lactation are available. However, due to the expected excretion of Rosuvastatin in the milk, women who are taking rosuvastatin should not breastfeed.

Driving Generally Safe

There are no studies of Rosuvastatin on driving ability. Do not drive unless you are feeling well.

Kidney Use With Care

Rosuvastatin should be used with caution in patients with kidney disease. Dose adjustment of Rosuvastatin is not necessary for mild to moderate renal impairment. 40mg Rosuvastatin cannot be used in patients with moderate renal impairment. Rosuvastatin cannot be used at all if the patient has severe renal impairment.

Liver Use With Care

Rosuvastatin should be used with caution in patients with liver disease. Dose adjustment of Rosuvastatin may be needed. However, Rosuvastatin is contraindicated for patients with active liver disease. Please consult your doctor.