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Amitriptyline is commonly used in the treatment of depression, bed wetting, insomnia, anxiety disorder, nerve pain, obsessive-compulsive disorder (ocd) and preventive treatment of migraine.
Amitriptyline increases the concentration of serotonin or norepinephrine in the central nervous system by blocking the reuptake of norepinephrine and serotonin in the neurons
Hypotension, Nightmares, Difficulty sleeping (insomnia), Restlessness, Confusion, Hallucinations, Dysarthria, Palpitation, Tremors, Dry mouth
It is unsafe to consume alcohol with Amitriptyline as it will aggravate the effect of confusion and drowsiness
Amitriptyline tablets may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus. However, there is a lack of human studies
In most cases, there were no adverse effects seen in breastfed infants. However, there are rare cases of amitriptyline cause sedation in the breastfed baby.
Do not drive unless you are feeling well. Amitriptyline may cause side effects such as sedation which could affect the ability to concentrate and drive.
Amitriptyline is one of the nephrogenic drugs. It may cause rhabdomyolysis and it is contraindicated in Chronic Renal Failure
Metabolism of Amitriptyline takes place in the liver. There are few cases of liver abnormalities reported such as acute hepatitis, prolonged jaundice, and cholestatic hepatitis