Chloramphenicol Oral

Information About Chloramphenicol Oral

Uses of Chloramphenicol Oral

Chloramphenicol Oral is commonly used to treat bacterial, eye, ear infections as well as meningitis.

How Chloramphenicol Oral Works

Chloramphenicol Oral is an antibiotic. It works by binding to the site of protein synthesis, specifically the 50s subunit protein of the bacteria's ribosome. Thus, it causes the destruction of bacterial proteins.

Side Effects of Chloramphenicol Oral

GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency, Hypersensitivity reactions (rashes, fever and angioedema) Eye drop: Blurred vision. Ear drops: Ototoxicity.

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Chloramphenicol Oral Related Warnings

Alcohol Safe

It is safe to have alcohol with Chloramphenicol Oral

Pregnancy Not Safe

Chloramphenicol Oral is not recommended in pregnant women. Some animal studies have shown side effects on the foetus, however, there are limited human studies. Benefits may outweigh the risk in pregnant woman so please consult your doctor.

Lactation Not Advisable

Chloramphenicol Oral is contraindicated to patients who are currently breastfeeding as Chloramphenicol Oral is excreted in the breastmilk and have cause adverse effects to breastfed infant such as loss of appetite and heavy vomitting.

Driving Not advisable

It is not advised to drive after taking Chloramphenicol Oral, especially if medication is taken in the form of eye drops as it may blur your vision causing disruption to the driver.

Kidney Use With Care

Chloramphenicol Oral should be used with caution in patients with significantly impaired renal disease kidney disease. Dose adjustments may be needed. Please consult your doctor before using it.

Liver Use With Care

Chloramphenicol Oral should be used with caution in patients with significantly impaired liver disease. Dose adjustments may be needed. Please consult your doctor before using it.