Dexamethasone

Information About Dexamethasone

Uses of Dexamethasone

Topical dexamethasone used to treat inflamed mouth and throat due to erosion or ulceration.

How Dexamethasone Works

Dexamethasone Topical is a long-acting synthetic corticosteroid that works by reducing inflammation through inhibition of the migration of leukocytes and reversal of the increased capillary permeability, thus suppressing the normal immune response.

Side Effects of Dexamethasone

Glaucoma, Cataract, Osteoporosis, Growth retardation, Peptic ulcer, Cushingoid features, Gastrointestinal upset, Pancreatitis, Increased susceptibility to infection, Vertebral compression fractures

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Dexamethasone Related Warnings

Alcohol Not Advisable

It is recommended to limit alcohol intake while on Dexamethasone because a high dose of dexamethasone or prolonged usage increases the risk of having peptic ulcer.

Pregnancy Not Safe

Dexamethasone Topical is able to cross the placenta as it can cause fetal abnormalities such as cleft palate and intra-uterine growth retardation as well as interfere with brain growth and development. It is prescribed to pregnant mother only if essential.

Lactation Use With Care

Even though dexamethasone is excreted in breast milk but there is no known effect on the baby. The decision whether to discontinue therapy or not during breastfeeding needs to be discussed with the doctor.

Driving Generally Safe

Dexamethasone Topical usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Cautious use of Dexamethasone is needed in patients with renal impairment as it may cause minimal fluid retention effect.

Liver Use With Care

Cautious use of Dexamethasone Topical is needed in patients with hepatic impairment as it may cause minimal fluid retention effect.