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Gefitinib is commonly used to treat non-small cell lung cancer
Gefitinib is a tyrosine kinase inhibitor which works by preventing autophosphorylation of tyrosine residue associated with the EGFR receptor.
Itchiness, Skin rashes, Nose bleed, Blood in urine, Dry mouth, Nausea, Vomiting, Eye pain, Fever, Diarrhea,
There is no clear contraindication on the consumption of alcohol when taking Gefitinib..
Animal studies have shown reproductive toxicity when using Gefitinib but there are limited human data available to conclude the safety profile during pregnancy. It is not recommended to be used during pregnancy due to its potential harm on the fetal development.
Gefitinib is excreted into rats breastmilk but no human data available to confim this. It is therefore not advisable for women undergoing treatment with Gefitinib to breastfeed due to its potential toxicity.
It is generally safe to drive when taking Gefitinib but caution should still be taken if some adverse effects of Gefitinib affects the ability and concentration to drive.
There is no dosage adjustment recommended for those with renal impairment with renal clearance more than 20ml/min. Caution and dosage adjustment is advisable for those with renal clearance less than 20ml/min.
Dosage adjustment is recommended for people with mild to moderate liver impairment with close monitoring and is contraindicated if the liver functions severely deteriorated.