Sacubitril

Information About Sacubitril

Uses of Sacubitril

Sacubitril is commonly used to treat heart failure

How Sacubitril Works

Sacubitril is a prodrug of Sacubitrilat which inhibits neprilysin that is responsible for breaking down natriuretic peptides

Side Effects of Sacubitril

Hypotension, Hyperkalaemia/Hypokalaemia, Decreased kidney function, Anaemia, Diarrhea, Heartburn, Hypoglycaemia, Dizziness, Headache, Vertigo

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Sacubitril Related Warnings

Alcohol Not Advisable

Alcohol may further lower the blood pressure caused by Sacubitril. Alcohol can also cause palpitation which will increase the workload of the heart, further worsen the heart function. Thus, it is not advisable to consume alcohol and Sacubitril concomitantly.

Pregnancy Limited Data

Human studies have shown reproductive toxicities such as reduced kidney function of the newborn. Thus, it is not advisable to be used during pregnancy. Please consult your doctor.

Lactation Limited Data

Excretion of Sacubitril is not known in human breast milk. Thus, it is not advisable to be used during breastfeeding as risks cannot be excluded. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Sacubitril may cause side effects such as dizziness or tiredness, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Dose adjustment is needed for patients with moderate to severe (eGFR<30ml/min/1.73m2) kidney impairment. It is not recommended to be used in patients with end-stage renal disease as there are no clinical data in this group of patients.

Liver Limited Data

Dose adjustment is needed for patients with moderate hepatic impairment. Sacubitril is contraindicated in patients with severe liver impairment.