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Valganciclovir is commonly used to treat cytomegaloviral retinitis in aids patients and prophylaxis of cytomegaloviral infections in immunocompromised patients.
Valganciclovir is an antiviral which will be converted into ganciclovir and phosphorylated into a triphosphate form by viral enzymes. This form will incorporate into the adenosine bases of viral DNA subsequently prevent viral DNA synthesis and their activities.
Abdominal pain, Diarrhea, Nausea, Vomiting, Headache, Insomnia, Allergy reaction, Decreased appetite, Visual disturbances, Cough, Shortness of breath, Liver dysfunction, Muscle/Joint pain, Fever, Tiredness
There is no known interaction between alcohol and Valganciclovir when used concomitantly.
Animal studies have shown reproductive toxicities caused by its active metabolite, Ganciclovir but the safety profile of Valganciclovir has not been established in pregnant women. Thus, Valganciclovir is not advisable to be used during pregnancy unless the benefits outweigh the risks. Please consult your doctor.
Animal studies have shown that its active metabolite, Ganciclovir is excreted in the milk but it is not known in human milk. Thus, breastfeeding is not recommended for patients who are receiving Valganciclovir treatment.
There are no studies of Valganciclovir on the ability to drive. Do not drive unless you are feeling well.
Valganciclovir dosage has to be adjusted according to the creatinine clearance of patients with kidney impairment. It is not advisable to be used in patients with creatinine clearance less than 10ml/min and patients requiring haemodialysis. Please consult your doctor.
The safety profile of Valganciclovir has not been established in patients with liver impairment. Thus, caution use has to be practised in such patients.
