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Zoledronic acid is commonly used to treat osteoporosis, osteoporosis in men, post menopausal osteoporosis, steroid induced osteoporosis
Zoledronic acid is able to inhibit farnesyl pyrophosphate synthase in the osteoclasts leading to reduction of osteoclastic activity and rate of bone resorption
Bone/Joint/Muscle pain, Dizziness, Fever, Flu-like symptoms, Allergy reaction, Nausea, Vomiting, Diarrhea, Eye inflammation, Alopecia
Although there is no known interaction between Zoledronic acid and alcohol, excessive alcohol intake can cause bone loss which opposes the therapeutic uses of Zoledronic acid.
Zoledronic acid usage is not advisable during pregnancy as animal studies have shown toxic effects on the foetus. However, the potential risk for pregnant women is not known.
Zoledronic acid usage is not advisable during breastfeeding as the excretion of zoledronic acid in human milk is unknown.
Do not drive unless you are feeling well. Zoledronic acid may cause side effects such as dizziness which could affect the ability to concentrate and drive.
No dose adjustment needed in patients with a creatinine clearance of more than 35ml/min. However, zoledronic acid usage is not advisable in patients with a creatinine clearance of less than 35ml/min.
Zoledronic acid is safe to use in patients with liver impairment.