Localized muscle spasm refers to muscle spasm that occurs in a particular area commonly the calf muscles. Muscle spasm, also known as muscle cramps is an involuntary contraction of muscles in the body. These sudden contractions are usually a response to muscle overexertion, dehydration, stress, and fatigue. Localized muscle spasm is often painful. There are many different types of muscles that are affected by spasm. In this case, the spasms affecting the skeletal muscles are the most common. Muscle spasms can occur due to risk factors such as the presence of peripheral artery disease, underlying neurological conditions, occupation, intense sports activities, smoking, alcohol consumption and environmental factors such as cold weather. Localized muscle spasms are usually relieved by painkillers, muscle stretchings, massages, rest, cold compressions on the affected area and rehydration. However, if the muscle spasms are not resolved and frequent recurrence persists, medical attention should be given to identify the cause of the spasm.