The cells and tissues in our body will keep on regenerating according to its life span or if the cells or tissue damage due to any trauma. Whenever the skin is injured, it will go through the wound healing process. The process includes several phases such as hemostasis phase, inflammatory phase, proliferative & regeneration phase, and maturation phase. The skin regeneration is a major phase of the process. It is completed with new tissue made up of collagen and extracellular matrix. It starts with the formation of a new network of blood vessels to supply the granulation tissue with oxygen and sufficient nutrients. The most abundant protein in the skin is collagen. Elastin which is another type of protein found in the skin also plays a major role in skin regeneration, giving structure and support. This concept has been the mainstay principle for numerous applications in cosmetic treatment in the aesthetic industry.