Acetaminophen

Information About Acetaminophen

Uses of Acetaminophen

Paracetamol is commonly used to treat joint pain, dental pain, fever, headache, migraine, muscle pain, pain during menstruation and post-operative pain.

How Acetaminophen Works

Paracetamol is an analgesic. It blocks the generation of pain impulses peripherally. It causes an antipyretic effect through inhibition of the hypothalamic heat-regulating center. The weak anti-inflammatory effect is due to inhibition of prostaglandin synthesis in the central nervous system.

Side Effects of Acetaminophen

Leucopenia, Thrombocytopenia, Pancytopenia, Angioedema, Nausea, Vomiting, Constipation, Headache, Insomnia, Hypotension .

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Acetaminophen Related Warnings

Alcohol Safe

It is safe to consume alcohol in small amount while taking paracetamol. Large quantities of alcohol may increase the risk of liver side effects.

Pregnancy Maybe Safe

There is no effect in pregnancy if paracetamol is used as the recommended dosage.

Lactation Safe If Prescribed

Paracetamol is excreted in human breast milk in very small amount, therefore it is safe to use Acetaminophen during breastfeeding.

Driving Generally Safe

Paracetamol usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

It is advisable to use paracetamol with caution in patients with severe renal impairment.

Liver Use With Care

It is advisable to use paracetamol with caution in patients with severe liver impairment. The effects of overdose are greater in patients with non-cirrhosis alcoholic liver disease. Delayed in treatment of overdose may also cause serious damage to the liver.