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Adefovir is commonly used to treat chronic hepatitis b virus hbv infection
Adefovir works by competitively inhibit a natural substrate that is essential for DNA replication of the virus.
Nausea, Diarrhea, Vomitting, Abdominal pain, Headache, Itchiness, Skin rash
Adefovir is safe to be consumed with alcohol as no evidence indicate otherwise.
The animal studies showed toxicity towards the fetus. However, human data is limited and it may be used with caution if the benefits outweigh the risk.
There is no human data to exclude the potential toxicity or presence of Adefovir in human breastmilk. Animal studies suggest there is toxicity risk and hence it is not advisable to breastfeed during the treatment with Adefovir.
There is no data studying the effects of Adefovir with driving but with the side effects profile, Adefovir may be used before driving.
Adefovir can cause renal impairment. Dose adjustment is needed for people with kidney disease and reduce creatinine clearance.
It is advisable to put patient on close monitoring in those with severe or cirrhotic liver disease. Treatment cessation is not needed as long as liver function is monitored.