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Alendronic acid is commonly used in the treatment of osteoporosis, osteoporosis in men, postmenopausal osteoporosis and steroid induced osteoporosis.
Alendronic acid is a bisphosphonate which is able to inhibit the activity of Farnesyl Pyrophosphate Synthetase, an enzyme which can increase the activity of osteoclast. Osteoclast is a protein which is responsible for breaking down and resorption of the bone, thus maintaining the bone integrity.
Abdominal pain, Dyspepsia, Diarrhea, Constipation, Oesophagitis, Oesophageal erosion/ulceration, Oesophageal stricture, Peptic ulceration, Osteonecrosis of the jaw, Bone/Joint/Muscle pain, Femoral fracture, Hypocalcemia, Steven Johnson syndrome, Toxic epidermal necrolysis
Alendronic acid has no interaction with alcohol.
There are no adequate data from the use of alendronic acid in pregnant women. Animal studies have shown reproductive toxicity which caused dystocia related to hypocalcemia in rats. Alendronic acid should not be used during pregnancy
It is not known whether alendronate/metabolites are excreted in human milk. A risk to the newborns/infants cannot be excluded. Alendronate not be used during breast-feeding.
Alendronic acid usually does not affect the ability to drive. Do not drive unless you are feeling well..
Do not require dose adjustment for patients with a glomerular filtration rate (GFR) greater than 35 ml/min. However, it is not recommended for patients with impaired renal function if the GFR is less than 35 ml/min, as there is no data of this.
No dose adjustment is necessary.
