Amlodipine+Valsartan

Information About Amlodipine+Valsartan

Uses of Amlodipine+Valsartan

Amlodipine and valsartan, when combined, belong to the class of antihypertensive agents and are indicated for the treatment of hypertension to lower blood pressure.

How Amlodipine+Valsartan Works

Amlodipine and Valsartan have complementary mechanisms of action. Amlodipine, a calcium channel blocker, inhibits calcium influx into vascular smooth muscle cells, leading to vasodilation and reduced peripheral resistance. Valsartan, an angiotensin II receptor blocker (ARB), blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II, further contributing to blood pressure reduction by relaxing blood vessels. Together, they provide an effective combination for the management of hypertension.

Side Effects of Amlodipine+Valsartan

Common side effects may include: Dizziness, Peripheral edema (swelling of the extremities), Flushing, Headache, Fatigue, Palpitations, Nasopharyngitis (inflammation of the nasal passages and throat)

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Amlodipine+Valsartan Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Amlodipine+Valsartan. Taking Amlodipine+Valsartan with alcohol may worsen the side effects of Amlodipine+Valsartan such as headache, dizziness and visual disturbance. Furthermore, amlodipine is metabolised in the liver and alcohol consumption leads to a risk of liver damage.

Pregnancy Not Safe

Amlodipine+Valsartan may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits of using Amlodipine+Valsartan among pregnant women outweigh the risks. Please consult your doctor.

Lactation Limited Data

Amlodipine+Valsartan is reported to be excreted into breast milk. However, the effect of the exposure towards the babies remains unknown. There is also stated that no side effects were reported with the exposure. Please consult your doctor for further details.

Driving Not advisable

Do not drive unless you are feeling well. Amlodipine+Valsartan may cause side effects such as dizziness headache, tiredness or nausea, all of which could affect the ability to concentrate and drive.

Kidney Use With Care

Amlodipine+Valsartan should be used with caution in patients with severe kidney disease. Amlodipine+Valsartan is mostly excreted via urine. Thus, dose adjustment of Amlodipine+Valsartan may be needed. Please consult your doctor.

Liver Use With Care

The liver disease should use Amlodipine+Valsartan with caution. It is extensively metabolised in the liver. Extensive use of Amlodipine+Valsartan also increases the liver enzyme. Dose adjustment of Amlodipine+Valsartan may be needed. Please consult your doctor.