Anagrelide

Information About Anagrelide

Uses of Anagrelide

Anagrelide is commonly used to treat essential thrombocytopenia

How Anagrelide Works

Anagrelide is a cyclic adenosine monophosphate phosphodiesterase III inhibitor. It reduces platelet production and inhibits platelet aggregation at high concentrations such as in patients with Essential Thrombocytopenia.

Side Effects of Anagrelide

Anaemia, Fluid retention, Dizziness, Tachycardia, Palpitation Diarrhea, vomiting, flatulence, abdominal pain, Rash, Fatigue

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Anagrelide Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Anagrelide. Taking Anagrelide may lead to side effects such as dizziness, fatigue and tachycardia or palpitations. Hence, consumption of both Alcohol and anagrelide may lead to additive effects that could be dangerous.

Pregnancy Not Safe

Anagrelide may be unsafe to use during pregnancy. Animal studies showed toxicity to the fetal development, however, there are limited human studies regarding the effect of Anagrelide on fetus. It should only be used if benefits outweigh the risks. Please consult your doctor.

Lactation Limited Data

Excretion of Anagrelide in human milk is unknown. Available data in animals have shown excretion of anagrelide/metabolites in milk. Breast-feeding should be discontinued during treatment with anagrelide as the risk to the newborn/infant cannot be excluded.

Driving Not advisable

Anagrelide commonly cause dizziness. If patient experiences side effects such as dizziness, it is not advisable to drive a car or operate machinery.

Kidney High Risk

Anagrelide is contraindicated in patients with moderate to severe kidney disease especially with less than CrC 50mL/min.

Liver High Risk

Anagrelide is contraindicated in patients with liver failure. Please consult your doctor.