Aspirin+Clopidogrel

Information About Aspirin+Clopidogrel

Uses of Aspirin+Clopidogrel

Aspirin and clopidogrel, when used in combination, belong to the class of antiplatelet agents and are indicated for the prevention of thrombotic events in patients at risk for cardiovascular disease.

How Aspirin+Clopidogrel Works

Aspirin and clopidogrel, both antiplatelet agents, act through different mechanisms to inhibit blood clot formation. Aspirin inhibits the enzyme cyclooxygenase, reducing the production of thromboxane A2 and thus preventing platelet aggregation. Clopidogrel, on the other hand, blocks the P2Y12 adenosine diphosphate (ADP) receptor on platelets, further inhibiting their activation and aggregation. Together, these drugs provide a dual antiplatelet effect, reducing the risk of thrombotic events.

Side Effects of Aspirin+Clopidogrel

Common side effects may include: Gastrointestinal disturbances (e.g., abdominal pain, dyspepsia), Bleeding events (e.g., bruising, nosebleeds), Diarrhea, Headache. DizzinessRash

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Aspirin+Clopidogrel Related Warnings

Alcohol Safe

It is safe to take alcohol with Aspirin+Clopidogrel. However, it is advisable to consume alcohol in moderate amount because drinking too much alcohol while on Aspirin+Clopidogrel might irritate the stomach.

Pregnancy Maybe Safe

Animal studies have failed to prove that there is a risk to the fetus and there are no adequate human studies. As no data is available, it is recommended not to use Aspirin+Clopidogrel during pregnancy.

Lactation Limited Data

There is limited human data on whether Aspirin+Clopidogrel is excreted in human breast milk. Animal studies demonstrated that Aspirin+Clopidogrel is excreted in breast milk. It is advisable that breastfeeding is discontinued following treatment with Aspirin+Clopidogrel.

Driving Generally Safe

Aspirin+Clopidogrel usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

There is limited study on the usage of Aspirin+Clopidogrel in patients with renal impairment. This, it is recommended that Aspirin+Clopidogrel should be used with caution in such patients.

Liver Limited Data

There is limited experience in patients with liver disease who may have bleeding tendencies. In such a population, Aspirin+Clopidogrel need to be used with caution.