Azathioprine

Information About Azathioprine

Uses of Azathioprine

Azathioprine is commonly used to treat autoimmune diseases such as nephrotic syndrome associated with lupus nephritis and rheumatoid arthritis, prevention of organ rejection in transplant patients

How Azathioprine Works

Azathioprine inhibits RNA, DNA and purine synthesis and coenzyme function and formation. Thus, it interferes with cellular metabolism and mitosis rendering the immunosuppressive effect.

Side Effects of Azathioprine

Viral, bacterial and fungal infections Depression of bone marrow function leading to leukopenia Thrombocytopenia

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Azathioprine Related Warnings

Alcohol Safe

It is safe to consume alcohol with Azathioprine as there is no interaction between them.

Pregnancy Not Safe

Azathioprine is unsafe to use during pregnancy. Human and animal studies have shown adverse effects on the fetus such as low birth weight, premature birth and spontaneous abortion. There is also evidence of haematological disorder in neonates whose mother took Azathioprine.

Lactation Not Advisable

Azathioprine metabolites such as 6-Mercaptopurine is found in colostrum and breast milk in women receiving the treatment. Thus, Azathioprine should be avoided in lactating women.

Driving Limited Data

Azathioprine's influence on ability to drive is unknown. Nevertheless, do not drive unless you are feeling well.

Kidney High Risk

Azathioprine's toxicity may be enhanced in patients with renal impairment but no controlled studies have supported this statement. Dose adjustment Azathioprine may be needed with haematological monitoring. Please consult your doctor.

Liver Use With Care

Azathioprine is metabolised in the liver. Thus, dose adjustment of Azathioprine may be needed with liver impairment. Please consult your doctor.