Bupropion

Information About Bupropion

Uses of Bupropion

Bupropion is commonly used to treat depression, smoking addiction

How Bupropion Works

Bupropion works by inhibiting the re-uptake of noradrenaline and dopamine into the neurons of the central nervous system. The mechanism of action is not fully known but is postulated to involve with serotonin re-uptake as well.

Side Effects of Bupropion

Headache, Nausea, Dry mouth, Constipation, Dizziness, Anxiety, Somnolence, Muscle weakness, Sweating, Insomnia, Hot flushes

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Bupropion Related Warnings

Alcohol Not Advisable

Bupropion and alcohol may potentiates each other side effects on the central nervous system. Therefore, it is not advisable to consume alcohol while on Bupropion treatment.

Pregnancy Not Safe

Animal studies do not indicate harmful effects on pregnancy or the fetus but based on human epidemiological studies, there have been reported of some adverse effects on fetal heart development. Bupropion should be used only under specialist supervision.

Lactation Limited Data

Bupropion has been found in traces in human breastmilk and the use of it during lactation should consider the benefit of breastfeeding against the benefit of the treatment.

Driving Not advisable

It is not advisable to take Bupropion before driving due to its side effects such as dizziness and somnolence which can affect the ability to drive and concentrate.

Kidney Use With Care

Bupropion is excreted into the urine and should, therefore, be monitored closely. Dose adjustment may be needed in patient with renal impairment.

Liver Limited Data

Bupropion should be used with caution in people with hepatic impairment as it is extensively metabolised by the liver. Patient with hepatic impairment may need close monitoring with the liver function and dosage adjustment accordingly.