Clomiphene

Information About Clomiphene

Uses of Clomiphene

Clomiphene/clomifene is commonly used to treat female infertility caused by anovulation (ovaries cannot release an egg during menstruation).

How Clomiphene Works

Clomiphene/Clomifene is an oestrogen analogue. It will inhibit the effect of negative feedback receptors located on a higher level and caused the secretion of hypothalamic GnRH hormone increases, therefore, increases the pituitary FSH and LH release.

Side Effects of Clomiphene

Ovarian Hyperstimulation Syndrome (OHSS), Visual disturbances, Endometriosis, Enlargement of ovary/ ovarian cyst formation, Nausea, Dizziness, Increase appetite, Weight gain, Fatigue, Vaginal dryness

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Clomiphene Related Warnings

Alcohol Not Advisable

Taking Clomiphene/Clomifene with alcohol may have additive effects in causing dizziness, nausea and vomiting.

Pregnancy Not Safe - High Risk

Clomiphene/Clomifene is unsafe to use during pregnancy. Both animal and human studies have shown adverse effects on the fetus. This medicine is strictly prohibited in pregnancy. Use of Clomiphene should be started only after pregnancy has been excluded.

Lactation Limited Data

Clomiphene/Clomifene has potential toxicity and not safe to use during lactation. No human data suggests that Clomiphene does not represent a significant risk to the baby. Clomiphene may reduce lactation in some patients.

Driving Not advisable

Do not drive unless you are feeling well. Clomiphene/Clomifene may cause side effects such as visual disturbances, dizziness, or lightheadedness, all of which could affect your ability to concentrate and drive.

Kidney Safe If Prescribed

Clomiphene/Clomifene is excreted mainly through faeces and it is probably safe in patients with kidney disease.

Liver Limited Data

Clomiphene/Clomifene is contraindicated in patients with liver disease because it metabolised in the liver; undergoes enterohepatic recirculation. Please consult your doctor.