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Clozapine is commonly used to treat mania, schizophrenia, psychosis in parkinson disease and suicidal behaviour in schizophrenia
Clozapine works by inhibiting the dopamine D2 receptor and serotonin type 2A receptor
Low blood pressure, Blackout, Seizure, Visual problem, Drooling of saliva, Urinary retention, Fast pulse, Dizziness, Insomnia, Headache
Clozapine and alcohol consumption may worsen the effects on the central nervous system as their adverse reactions may be compounded.
Animal reproductive studies did not suggest any harm on Clozapine use but reports from human studies especially on the use of Clozapine on the third trimester suggest some risk to the neonates. Careful monitoring by specialists is advisable.
Cilostazol has been found in breastmilk according to animal studies and due to its potential serious side effects on the infant, it is not advisable to be used during breastfeeding.
It is not advisable to drive when taking Clozapine due to its potential side effects such as headache and dizziness which can affect the ability to drive and concentrate.
Dosage adjustment is needed in patients with mild to moderate renal impairment and is contraindicated to be used in patients with severe renal impairment.
Dosage adjustment is needed in patient with mild to moderate hepatic impairment while it is contraindicated to be used in severe hepatic impaired patients.
