Cyclosporine

Information About Cyclosporine

Uses of Cyclosporine

Cyclosporine is commonly used to atopic dermatitis, bone marrow transplantation, nephrotic syndrome associated with lupus nephritis and focal segmental glomerulosclerosis, prevention of organ rejection in transplant patients, psoriasis, rheumatoid arthritis, uveitis

How Cyclosporine Works

Cyclosporine is an immunosuppressant. It works by inhibiting the production and release of interleukin II. It also inhibit interleukin II-induced activation of resting T-lymphocytes.

Side Effects of Cyclosporine

Tremor, Headache , Low white cell counts (Low white cell counts), Hyperlipidemia (high fat in blood vessel), Numbness (Paraesthesia) , Convulsion, Hypertension, Flushing, Nausea and, vomiting, Hirsutism, Muscle cramps, Renal dysfunction, Fatigue

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Cyclosporine Related Warnings

Alcohol Safe

There is no interaction between Alcohol and cyclosporine. Hence, it is safe to consume alcohol with cyclosporine.

Pregnancy Not Safe

Cyclosporine may be unsafe to use during pregnancy. There is limited human studies that have shown adverse effects on the fetus. However, animal studies have shown evidence of fetal reproductive toxicity. It is permissible to use Cyclosporine if the benefits balanced off the risks. Please consult your doctor.

Lactation Not Advisable

It is not safe to take Cyclosporine whilst breastfeeding as Cyclosporine is found to be excreted in human milk.

Driving Not advisable

Cyclosporine may cause headache, convulsion, fatigue and tremor. These side effects could affect your ability to concentrate and drive. Hence, it is not advisable to drive whilst on Cyclosporine.

Kidney High Risk

Cyclosporine should not be used in patients with abnormal kidney function.

Liver Use With Care

Dose adjustment of Cyclosporine may be needed in patients with liver disease as the metabolism the medication is extensively by the liver.