Danazol

Information About Danazol

Uses of Danazol

Danazol is commonly used to treat benign fibrocystic breast disease, endometriosis, heavy menstrual bleeding and hereditary angioedema.

How Danazol Works

Danazol inhibits the pituitary secretion of FSH and LH, resulting in atrophy of normal and ectopic endometrial tissue. It also decreases the growth rate of abnormal breast tissues and reduces attacks of hereditary angioedema by increasing C4 levels of the complement system.

Side Effects of Danazol

Androgenic effects (e.g. acne, seborrhoea, wt gain, hair loss, voice change, clitoral hyperthrophy), Emotional lability, Headache, Increased heart rate, Vaginal irritation, Abnormal semen quality, Menstrual disturbances, Rash.

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Danazol Related Warnings

Alcohol Not Advisable

It is not recommended to consume alcohol with danazol as it can cause side effects of shortness of breath.

Pregnancy Not Safe - High Risk

Both human and animal studies demonstrated adverse effects of Danazol on the fetus in a pregnant woman. It is not recommended for use during pregnancy. Please consult your doctor before using it.

Lactation Not Advisable

Danazol is best avoided during lactation. It is excreted into human milk and could cause androgenic effect on a nursing baby. Please consult your doctor before using it.

Driving Generally Safe

Danazol cause no side effects which could affect your concentration and on your ability to drive.

Kidney Use With Care

Danazol should be used with care in patients with kidney disease. Dose adjustment and monitoring of renal function is required. Please consult your doctor before using it.

Liver Use With Care

Danazol should be used with care in patients with liver disease. Dose adjustment and monitoring of liver function is required. Please consult your doctor before using it.