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Dutasteride is commonly used in the treatment of benign prostatic hyperplasia and hair loss.
Dutasteride acts as a selective inhibitor of steroid 5alpha�-reductase isoenzymes type 1 (skin and hepatic) and type 2 (reproductive tissues). As a result, the conversion of testosterone to dihydrotestosterone is inhibited and thus serum dihydrotestosterone levels are suppressed.
Ejaculation disorder, Impotence, Decreased libido, Breast cancer, Breast tenderness, Rash, Urticaria, Testicular pain and swelling, Depressed mood, Localized edema
It is not advisable to use dutasteride with alcohol because alcohol may dehydrate and cause difficult urination. The symptoms may also get worse thus, it is recommended to avoid or limit alcohol while taking dutasteride. There are few studies which reported that alcohol can affect prostate cancer prevention in patients taking dutasteride or other α-reductase inhibitors.
When dutasteride is given to a pregnant woman with a male fetus, it will inhibit the development of external genitalia of the fetus. Small amounts of dutasteride have been found from the semen in subjects taking them, though it is unknown whether a male fetus can be affected if his mother is exposed to such semen.
It remains unknown whether dutasteride is excreted in human breast milk. But it is contraindicated in women of child-bearing potential
Dutasteride usually does not affect the ability to drive. Do not drive unless you are feeling well.
There is limited data on the usage of dutasteride in patients with renal impairment. However, dosage adjustment is not expected for such patients.
In patients with mild to moderate liver impairment, it is important to use Dutasteride with caution. It should be avoided at all cost in patients with severe liver disease.
