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Entacapone is commonly used to treat parkinson's disease
Entacapone is a catechol-O-methyl transferase (COMT) inhibitor which is usually given in combination with levodopa as it decreases the conversion of levodopa to 3-O-methyldopa (3-OMD) peripherally and leads to higher availability and clinical response of levodopa for the brain.
Nausea, Vomiting, Abdominal pain, Constipation, Diarrhea, Dry mouth, Insomnia, Dyskinesia, Parkinsonism, Dizziness, Somnolence, Dystonia, Hyperkinesia, Urine discoloration, Ischaemic heart disease
It is unsafe to consume alcohol with Entacapone because Alcohol can exaggerate the nervous system side effects of entacapone such as dizziness and dyskinesia.
Entacapone may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may outweigh the risk. Please consult your doctor before using it.
Entacapone is excreted into the breastmilk during animal studies. However, its effect on feeding infants is largely unknown. Hence, Entacapone is not recommended for use in breastfeeding women.
Entacapone may cause side effects such as dizziness and somnolence all of which could affect your ability to concentrate and drive. Do not drive unless you're feeling well.
The excretion of Entacapone is not affected in patients with kidney disease unless they are on dialysis. Dose adjustment is not indicated in patients with kidney disease without dialysis. Please consult your doctor before using it.
Entacapone should be used with caution in patients with liver disease. Dose adjustment of Entacapone may be needed. Please consult your doctor before using it.
