Erlotinib

Information About Erlotinib

Uses of Erlotinib

Erlotinib is commonly used to treat pancreatic cancer and small cell lung cancer.

How Erlotinib Works

Erlotinib causes cellular apoptosis and decreases tumour size by inhibiting epidermal growth factor receptor/human epidermal growth factor receptor type 1 (EGFR/HER1) tyrosine kinase involved in the signalling pathway of cancers.

Side Effects of Erlotinib

Rash, Dry skin, Diarrhea, Nausea, Vomiting, Stomatitis, Abdominal pain, Anorexia, Alopecia, Nail changes such as paronychia, Conjunctivitis, Epistaxis, Fatigue

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Erlotinib Related Warnings

Alcohol Not Advisable

Taking alcohol with Erlotinib may aggravate side effects of the medication. Please consult your doctor before consuming it.

Pregnancy Not Safe

Erlotinib may be unsafe to use during pregnancy. Animal studies have shown teratogenicity and fetal lethality on the fetus, however, there are limited human studies. The benefits from use in pregnant women may outweigh the risk. Please consult your doctor before consuming it.

Lactation Limited Data

It is not known whether Erlotinib is excreted into breast milk and its potential side effects on feeding infant is largely unknown. Breastfeeding women is strongly advised to stop feeding when started on this therapy.

Driving Generally Safe

Erlotinib may cause negligible side effects on your ability to concentrate and drive. Do not drive unless you're feeling well.

Kidney Use With Care

Renal excretion of Erlotinib is not affected significantly in patients with kidney disease. Please consult your doctor before using it. Use of Erlotinib is not recommended in patients with severe kidney disease as data is still unavailable.

Liver Limited Data

Erlotinib should be used with caution in patients with liver disease. Dose adjustment of Erlotinib and close monitoring of liver function may be needed. Please consult your doctor before using it.