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Lamotrigine is commonly used to treat bipolar disorder, epilepsy, epileptic seizures, mania, migraine, seizures, trigeminal neuralgia
Lamotrigine stabilises presynaptic neuronal membranes by blocking voltage sensitive Na channels, subsequently inhibiting the release of neurotransmitters
Aggression, Irritability, Difficulty sleeping (insomnia), Headache, Tremor Somnolence, Nausea and vomiting, Joint pain, Fatigue, Rash
It is unsafe to consume alcohol with Lamotrigine. Taking Lamotrigine with alcohol may have additive effects in central nervous system. It increases the risk of CNS depression.
Lamotrigine may be unsafe to use during pregnancy. Nevertheless, sudden discontinuation will lead to detrimental effect to both fetus and mother. Monotherapy is better than multiple antiepileptic commencement as they reduce the risk of congenital malformation.
Lamotrigine may be unsafe to use during lactation as there are risks of sedation, poor weight gain and rash if administered due to the potential benefits of breast-feeding outweigh the potential risk of adverse effects occurring in the infant.
There is no study regarding the influence of Lamotrigine on the ability to drive. Nevertheless, there are reported cases of double vision and dizziness whilst driving. Therefore, patients should not drive if such adverse effects happen.
Caution should be exercised when patients with renal failure take Lamotrigine. Dose adjustment of Lamotrigine may be needed. Please consult your doctor.
Lamotrigine should be used with caution in patients with liver disease. Dose titration of Lamotrigine may be needed according to level of liver deterioration. Please consult your doctor.