Lopinavir

Information About Lopinavir

Uses of Lopinavir

Lopinavir is commonly used to treat hiv infection

How Lopinavir Works

Lopinavir is used in combination with Ritonavir. It inhibits an enzyme, HIV protease to be incapable of processing the polyprotein precursor. This leads to the production of non-infectious and immature HIV particles.

Side Effects of Lopinavir

Diarrhea, Abdominal pain, Headache, Indigestion (Dyspepsia), Vomiting, Palpitation, Agitation and confusion, Tinnitus, Acne, Dry skin and skin discoloration

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Lopinavir Related Warnings

Alcohol Safe

It is safe to consume alcohol with Lopinavir as there is no known drug interactions.

Pregnancy Limited Data

Lopinavir may be safe to use during pregnancy if it is clinically indicated. Human studies have not shown any adverse effects to fetal formation.

Lactation Limited Data

It is not known whether Lopinavir is excreted in human milk. Adverse risk effect cannot be excluded. Therefore, it is not recommended for Lopinavir to be used during lactation. Also, mothers with HIV should avoid breastfeeding their babies to avoid transmission.

Driving Limited Data

There is no information regarding the effects of Lopinavir whilst driving. However, patients should be informed that there is a risk of nausea when taking Lopinavir.

Kidney High Risk

Lopinavir is contraindicated in patients with kidney failure.

Liver Limited Data

In patients with liver disease, the use of Lopinavir is contraindicated.