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Memantine is commonly used in the treatment of alzheimer's disease.
Memantine is a N-methyl-D-aspartate-receptor (NMDA receptor) antagonist which works by binding to NMDA-receptor and inhibits glutamate, an excitatory neurotransmitter in the CNS because in Alzheimer's disease, Glutamate overstimulates glutamate receptors resulting in neuronal dysfunction.
Headache, Somnolence, Dizziness, Constipation, Hypertension, Dyspnea, Abnormal gait, Hypertonia, Fungal infections, Cystitis, Thromboembolism, Increased libido, Psychotic reactions
There is no data showed the interaction of memantine with alcohol, however, it is not advisable to take both of them at the same time based on the fact that alcohol will double the side effects if memantine such as dizziness, headache, nausea, vomiting and confusion.
Neither animal or human studies have shown adverse effect of Memantine on the fetus in the first trimester, as well as in later trimester. Limited studies done on pregnant women because of the usage of Memantine in treating Alzheimer's disease, which is commonly found in older age. Please consult your doctor before usage.
No data have found about lactation safety while consuming Memantine. However, the fact that memantine has lipophilic character, it has to potential to be excreted in breast milk. Please stop breastfeeding if you are consuming Memantine.
Alzheimer's disease itself impairs your ability to drive alone and with the addition of memantine, your driving impairment will be affected even more. Family members should receive prior warnings.
Dose adjustment for Memantine may be needed in patients with moderate-to-severe kidney impairment. Please consult your doctor.
Memantine should be used with caution in patients with mild to moderate liver disease but its use is not recommended in severe type. Please consult your doctor.
