Palbociclib

Information About Palbociclib

Uses of Palbociclib

Palbociclib is commonly used to treat hormone receptor positive breast carcinoma.

How Palbociclib Works

Palbociclib is a reversible, selective inhibitor of cyclin-dependent kinase (CDK) 4 and 6. Cyclin D1, CDK 4 and 6 are enzymes in the multiple signalling pathways of tumour cell proliferation.

Side Effects of Palbociclib

Low white blood cell count, Susceptible to infections, Fatigue, Nausea, Stomatitis, Low red blood cell count, Alopecia, Rash, Diarrhea, Vomiting, Decreased appetite, Vision blurred

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Palbociclib Related Warnings

Alcohol Safe

Consuming alcohol in moderation does not seem to cause pharmacodynamic changes with Palbociclib. However, please consult your doctor before using it,

Pregnancy Limited Data

Palbociclib may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The medication is not recommended for use in pregnant women. Please consult your doctor before using it.

Lactation Limited Data

Data of Palbociclib excretion into breast milk and its potential adverse effect on feeding baby is largely unknown. Please consult your doctor before using it.

Driving Not advisable

Palbociclib may cause side effects of blurred vision and fatigue all of which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.

Kidney Safe If Prescribed

Palbociclibs's pharmacodynamic is not significantly affected in patients with kidney disease. Dose adjustment of Palbociclib may not be needed. Please consult your doctor before using it.

Liver Limited Data

Palbociclib should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Palbociclib may be needed in severe liver disease. Please consult your doctor before using it.