Papain

Information About Papain

Uses of Papain

Papain is commonly used to treat oedema and inflammation.

How Papain Works

Papain is a cysteine protease enzyme that is found in species of papaya. When applied topically, papain induces an allergen-like inflammatory response by recruiting neutrophils, mast cells, and CD3-positive cells and by induction of a TH2-biased antibody response.

Side Effects of Papain

Urticaria, Pruritus, Dizziness, Nausea, Vomiting, Diarrhea, Sensitisation,

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Papain Related Warnings

Alcohol Limited Data

Certain food and medications will have interactions with concurrent use of Papain but there is no specific data stating so. Please consult your doctor before using it.

Pregnancy Limited Data

Papain is not indicated for usage during pregnancy. Since animal studies or human studies have not shown adverse effects on the fetus, please consult your doctor before using it.

Lactation Limited Data

Papain excretion into breast milk and its effect on feeding baby is still unknown. Please discuss with your doctor before using it.

Driving Limited Data

Papain's side effects on your ability to concentrate and drive is unknown. Do not drive unless you are feeling well.

Kidney Use With Care

Due to limited data, Papain should be used with caution in patients with kidney disease. Dose adjustment of Papain may be needed. Please consult your doctor before using it.

Liver Limited Data

Due to limited data, Papain should be used with caution in patients with liver disease. Dose adjustment of Papain may be needed. Please consult your doctor before using it.