Proguanil

Information About Proguanil

Uses of Proguanil

Proguanil is commonly used to treat cerebral malaria, malaria, prevention of malaria

How Proguanil Works

Proguanil is an antimalarial agent. It prevents nucleic acid synthesis in the parasite by inhibiting enzyme, plasmodial dihydrofolate reductase and thus killing the parasite.

Side Effects of Proguanil

Mild gastric intolerance Diarrhea Constipation aphthous ulceration Urticaria Angioedema Reversible hair loss

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Proguanil Related Warnings

Alcohol Safe

It is safe to consume alcohol with Proguanil as there is no known drug interaction.

Pregnancy Limited Data

There are limited human studies of the use of Proguanil in pregnancy. It should not be used in pregnancy unless the benefits from use in pregnant women outweigh the risks. Please consult your doctor.

Lactation Safe If Prescribed

Proguanil is found to be excreted in human breast milk. However, the amount is negligible.

Driving Generally Safe

Do not drive unless you are feeling well. There is no evidence that Proguanil may affect the ability to drive and general concentration.

Kidney Use With Care

Proguanil should be used with caution in patients with kidney disease. Dose titration of Proguanil according to clinical status may be needed. Please consult your doctor.

Liver Safe If Prescribed

There is no information regarding the safety of Proguanil in patient with liver disease.