Prucalopride

Information About Prucalopride

Uses of Prucalopride

Prucalopride is commonly used to chronic idiopathic constipation.

How Prucalopride Works

Prucalopride's exerts its effect by binding to selective 5-HT4 receptor, stimulating intestinal secretions, peristaltic reflex, and gastrointestinal motility.

Side Effects of Prucalopride

Headache, Dizziness, Fatigue, Nausea and vomiting, Diarrhea, Abdominal pain, Dyspepsia, Flatulence, Decreased appetite

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Prucalopride Related Warnings

Alcohol Safe

Prucalopride has no effect on the metabolism of alcohol.

Pregnancy Limited Data

Prucalopride is not recommended for the usage of women in the reproductive age who practice unprotected coitus.

Lactation Limited Data

Prucalopride is excreted into the breast milk and safe to use during lactation at therapeutic dose. Limited human data suggests that Prucalopride does not represent a significant risk to the baby. Please consult your doctor to be sure.

Driving Not advisable

Do not drive unless you are feeling well. Prucalopride may cause side effects such as dizziness or tiredness, all of which could affect the ability to concentrate and drive.

Kidney Use With Care

Prucalopride should be used with caution in patients with severe kidney impairment. Dose adjustment of Prucalopride may be needed for patients with creatinine clearance less than 30 mL/min. Please consult your doctor.

Liver Limited Data

You may start Prucalopride with 1 mg once daily for patients with severe hepatic impairment (Child-Pugh class C) and may be increased to 2 mg if tolerated with Prucalopride. However, for patients with mild to moderate liver disease, no dose adjustment is needed.