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Ranolazine is commonly used in the treatment of angina heart related chest pain.
Ranolazine inhibits the late Na current and other cardiac ion channels and transporters. It reduces the magnitude of the late Na current resulting in reduction intracellular Na concentrations, reversal of Ca overload, restoration of ventricular pump function, and prevention of ischemia-induced arrhythmias.
Nausea and vomiting, Dizziness, Headache, Constipation, Palpitations, Vertigo, Visual disturbances, Tinnitus, Dry Mouth, Abdominal pain, Hypotension, Haematuria
It is unsafe to consume alcohol with Ranolazine because it may worsen the side effects of Ranolazine such as headache, dizziness, nausea, and palpitations.
Ranolazine may be unsafe to use during pregnancy. Animal studies have shown adverse reactions on the fetus, however, there are limited human studies. Hence, it is only used when clearly necessary. Please consult your doctor.
No reports explaining the use of ranolazine for breastfeeding mothers are available. Animal studies have shown the excretion of ranolazine in milk. Therefore, it should not be used during breast-feeding as we may not know the side effects.
There are no studies of Ranolazine on driving ability. However, it may cause some side effects which may affect driving ability. Do not drive when not feeling well.
Ranolazine should be used with caution in patients with mild and moderate kidney disease. Dose adjustment of Ranolazine may be needed. However, for patients with creatinine clearance less than 30 mL/min, Ranolazine is contraindicated. Please consult your doctor.
Ranolazine should be used with caution in patients with a history of liver disease. Dose adjustment of Ranolazine may be needed in mild liver impairment. However, Ranolazine is contraindicated for patients with moderate to severe hepatic impairment. Please consult your doctor.
