Selegiline

Information About Selegiline

Uses of Selegiline

Selegiline is commonly used to treat parkinson's disease

How Selegiline Works

Selegiline is a monoamine oxidase-B inhibitor which blocks the metabolism of dopamine in nigrostriatal pathways and increasing the dopaminergic activity.

Side Effects of Selegiline

Postural hypotension, Chest pain, Headache, Tremor, Vertigo, Dizziness, Mental disturbances, Gut disturbances, Difficulty in urination, Skin reactions, Joint/Muscle pain, Insomnia, Abnormal dreams, Liver enzyme dysfunction

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Selegiline Related Warnings

Alcohol Not Advisable

Alcohol may accentuate the sedative effect caused by Selegiline. Thus, it is not advisable to use alcohol and Selegiline concomitantly.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities but there are limited data on the use of Selegiline during pregnancy as Parkinson's Disease usually occur after childbearing age. Thus, it is advisable to avoid Selegiline during pregnancy.

Lactation Not Advisable

There are limited data on the use of Selegiline during breastfeeding. Thus, it is advisable to avoid Selegiline during breastfeeding.

Driving Not advisable

Do not drive unless you are feeling well. Selegiline may cause side effects such as dizziness, headache, nausea or tiredness, all of which could affect your ability to concentrate and drive.

Kidney Safe If Prescribed

Selegiline is safe to be used in patients with kidney impairment.

Liver Use With Care

Selegiline is safe to be used in patients with liver impairment.