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Sodium valproate is commonly used in the treatment of bipolar disorder, epilepsy, migraine and seizures
Sodium Valproate works by increasing the gamma amino-butyric acid (GABA), an inhibitory neurotransmitter to brain neurons. It has an enhancement effect on the action of GABA and also mimics its action at postsynaptic receptor sites.
Nausea, Vomiting, Diarrhea, Liver injury, Tremor, Headache, Somnolence, Confusion, Hallucination, Hypersensitivity
It is not advisable to consume alcohol with sodium valproate as the former can worsen central nervous system and cause side effects such as dizziness, drowsiness and impaired concentrations.
Sodium valproate is associated with congenital malformations and developmental disorders based on available human studies, however, it can still be used if no other alternative is suitable.
Valproate is excreted in human breast milk with a concentration of 1% to 10% of serum levels in mother. Hematological disorders in breastfed infants of mother on treatment has been found. The decision to discontinue Sodium Valproate or breastfeeding should be balance by the benefits of breastfeeding to the infant or benefits of treatment to the mother.
Do not drive unless you are feeling well. Sodium Valproate may cause side effects such as brief drowsiness which could affect the ability to concentrate and drive.
Sodium valproate should be used with caution in patients with renal impairment. Dose adjustment is indicated based on clinical monitoring.
It has been reported that sodium valproate may cause fatalities in patients with liver dysfunction, even though the incident is quite rare.