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Sodium Valproate

Information About Sodium Valproate

Uses of Sodium Valproate

Sodium valproate is commonly used in the treatment of bipolar disorder, epilepsy, migraine and seizures

How Sodium Valproate Works

Sodium Valproate works by increasing the gamma amino-butyric acid (GABA), an inhibitory neurotransmitter to brain neurons. It has an enhancement effect on the action of GABA and also mimics its action at postsynaptic receptor sites.

Side Effects of Sodium Valproate

Nausea, Vomiting, Diarrhea, Liver injury, Tremor, Headache, Somnolence, Confusion, Hallucination, Hypersensitivity

Information Updated on : Wed Jul 17 2024 10:49:00 GMT+0800 (Malaysia Time)

Sodium Valproate Related Warnings

Alcohol Not Advisable

It is not advisable to consume alcohol with sodium valproate as the former can worsen central nervous system and cause side effects such as dizziness, drowsiness and impaired concentrations.

Pregnancy Not Safe - High Risk

Sodium valproate is associated with congenital malformations and developmental disorders based on available human studies, however, it can still be used if no other alternative is suitable.

Lactation Limited Data

Valproate is excreted in human breast milk with a concentration of 1% to 10% of serum levels in mother. Hematological disorders in breastfed infants of mother on treatment has been found. The decision to discontinue Sodium Valproate or breastfeeding should be balance by the benefits of breastfeeding to the infant or benefits of treatment to the mother.

Driving Not advisable

Do not drive unless you are feeling well. Sodium Valproate may cause side effects such as brief drowsiness which could affect the ability to concentrate and drive.

Kidney Use With Care

Sodium valproate should be used with caution in patients with renal impairment. Dose adjustment is indicated based on clinical monitoring.

Liver Limited Data

It has been reported that sodium valproate may cause fatalities in patients with liver dysfunction, even though the incident is quite rare.

Frequently Asked Questions on Sodium Valproate

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