Solifenacin

Information About Solifenacin

Uses of Solifenacin

Solifenacin is commonly used to treat overactive bladder (oab) symptoms.

How Solifenacin Works

Solifenacin is a competitive muscarinic receptor inhibitor which has a higher affinity for the muscarinic receptors in the detrusor muscle of the bladder. It helps to prevent smooth muscle contraction of the bladder

Side Effects of Solifenacin

Constipation, Heartburn, Nausea, Abdominal pain, Hypertension, Oedema, Headache, Fatigue, Urinary tract infection, Blurred vision

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Solifenacin Related Warnings

Alcohol Safe

There is no known interaction between alcohol and Solifenacin when used concomitantly.

Pregnancy Not Safe

Animal studies have not shown any reproductive toxicities and there are no data on the use of Solifenacin in pregnant women. Thus, it is not advisable to be used unless clearly indicated. Please consult your doctor.

Lactation Not Advisable

Excretion of Solifenacin has been found in animal milk and caused negative effects on breastfed animal. However, there are no data on the excretion of Solifenacin in human breastmilk. Thus, it is not advisable to be used during breastfeeding.

Driving Not advisable

Do not drive unless you are feeling well. Solifenacin may cause side effects such as blurring of vision, sleepiness or tiredness, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

No dose adjustment needed for patients in mild to moderate kidney impairment. However, caution use has to be practised in patients with severe kidney impairment (creatinine clearance less than 30ml/min). Please consult your doctor.

Liver Use With Care

No dose adjustment needed for patients in mild liver impairment. However, caution use has to be practised in patients with moderate to severe liver impairment. Please consult your doctor.