Sunitinib

Information About Sunitinib

Uses of Sunitinib

Sunitinib is commonly used to treat gastrointestinal stromal tumour, kidney cancer and pancreatic cancer.

How Sunitinib Works

Sunitinib inhibits the signal transduction pathways and mediators which are involved in tumour growth and metastatic progression

Side Effects of Sunitinib

Reduced white blood cells/red blood cells/platelets, Hypothyroidism, Decreased appetite, Insomnia, Headache, Dizziness, Taste disturbances, Hypertension, Shortness of breath, Spontaneous nose bleed, Hand and foot skin reaction, Gut disturbances, Heart arrhythmia

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Sunitinib Related Warnings

Alcohol Not Advisable

Consumption of alcohol may accentuate the gut disturbances caused by Sunitinib. Thus, it is not advisable to consume alcohol while receiving treatment of Sunitinib. Please consult your doctor.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities but there are no data on the use of Sunitinib in pregnant women. Thus, it is not advisable to be used during pregnancy. Please consult your doctor.

Lactation Not Advisable

Animal studies have shown the excretion of Sunitinib in animal milk but it is not known in human milk. Thus, it is not advisable to be used during breastfeeding. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Sunitinib may cause side effects such as headache, dizziness or fatigue, all of which could affect your ability to concentrate and drive.

Kidney Safe If Prescribed

Sunitinib is safe to be used in patients with kidney impairment and indicated to be used for renal cell carcinoma.

Liver Use With Care

No dose adjustment needed for patients with mild to moderate liver impairment. However, Sunitinib is contraindicated in patients with severe liver impairment.