Voriconazole

Information About Voriconazole

Uses of Voriconazole

Voriconazole is commonly used to treat fungal infections and severe fungal infections

How Voriconazole Works

Voriconazole is an antifungal agent which binds to CYP450-dependent 14-alpha sterol demethylase, leading to the inhibition of ergosterol synthesis and destroying the fungal cell membrane.

Side Effects of Voriconazole

Allergy reaction, Visual disturbances, Gut disturbances, Liver dysfunction, Tachycardia, Headache

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Voriconazole Related Warnings

Alcohol Safe

There is no known interaction between Voriconazole and alcohol. However, possibility of interactions cannot be excluded. Please consult your doctor.

Pregnancy Not Safe

Animal studies have shown reproductive toxicity but there are limited data of Voriconazole on pregnant women. Thus, it is not advisable during pregnancy unless the benefits outweigh the risks. Please consult your doctor.

Lactation Limited Data

Excretion of Voriconazole into human milk has not been investigated. It is not advisable during breastfeeding. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Voriconazole may cause side effects such as brief visual disturbance or sensitive to bright light, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Oral preparations of Voriconazole are safe to use in patients with kidney impairment. However, intravenous preparations of Voriconazole has to be avoided and switch to oral preparation in patients with creatinine clearance less than 50ml/min.

Liver Limited Data

Dose adjustment of Voriconazole may be needed in patients with mild to moderate liver impairment. Caution use has to be exercised in patients with severe liver impairment as there are no studies of Voriconazole in this group of patients.