Zoledronic acid

Information About Zoledronic acid

Uses of Zoledronic acid

Zoledronic acid is commonly used to treat osteoporosis, osteoporosis in men, post menopausal osteoporosis, steroid induced osteoporosis

How Zoledronic acid Works

Zoledronic acid is able to inhibit farnesyl pyrophosphate synthase in the osteoclasts leading to reduction of osteoclastic activity and rate of bone resorption

Side Effects of Zoledronic acid

Bone/Joint/Muscle pain, Dizziness, Fever, Flu-like symptoms, Allergy reaction, Nausea, Vomiting, Diarrhea, Eye inflammation, Alopecia

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Zoledronic acid Related Warnings

Alcohol Not Advisable

Although there is no known interaction between Zoledronic acid and alcohol, excessive alcohol intake can cause bone loss which opposes the therapeutic uses of Zoledronic acid.

Pregnancy Not Safe

Zoledronic acid usage is not advisable during pregnancy as animal studies have shown toxic effects on the foetus. However, the potential risk for pregnant women is not known.

Lactation Not Advisable

Zoledronic acid usage is not advisable during breastfeeding as the excretion of zoledronic acid in human milk is unknown.

Driving Not advisable

Do not drive unless you are feeling well. Zoledronic acid may cause side effects such as dizziness which could affect the ability to concentrate and drive.

Kidney Use With Care

No dose adjustment needed in patients with a creatinine clearance of more than 35ml/min. However, zoledronic acid usage is not advisable in patients with a creatinine clearance of less than 35ml/min.

Liver Use With Care

Zoledronic acid is safe to use in patients with liver impairment.