Bicalutamide

Information About Bicalutamide

Uses of Bicalutamide

Bicalutamide is commonly used to treat prostate cancer

How Bicalutamide Works

Bicalutamide works by competitively inhibit the androgen from binding onto its receptor in the target tissue. This, in turn, prevents the androgen-dependent protein and DNA synthesis in the tumour.

Side Effects of Bicalutamide

Decreased appetite, Weight gain, Dehydration, Decrease libido, Lips swelling, Dizziness, Somnolence, Hot flushes, Constipation, Nausea

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Bicalutamide Related Warnings

Alcohol Not Advisable

Alcohol may exacerbate the side effects of Bicalutamide such as facial flushing and dizziness. It is therefore not advisable to be consumed together.

Pregnancy Not Safe - High Risk

Bicalutamide is contraindicated to be used in women and hence during pregnancy as well due to its potential serious adverse effects on the women and the fetus.

Lactation Not Advisable

Since it is not safe to be used by women, it is also contraindicated for breastfeeding mother to use Bicalutamide.

Driving Not advisable

It is not advisable to drive while taking Bicalutamide as it can cause side effects such as dizziness and somnolence all of which can alter the concentration and ability to drive.

Kidney Use With Care

Bicalutamide is excreted via urine and the use of it mild to moderate renal impairment does not require dose adjustment. However, in severe renal impairment, caution should be taken and dose adjustment may be required.

Liver Use With Care

Bicalutamide is extensively metabolised by the liver and caution should be taken in moderate to severe hepatic impairment. Regular liver function test should be taken and alternative treatment should be considered in high-risk patients.