Cilastatin

Information About Cilastatin

Uses of Cilastatin

Cilastatin is commonly used to treat severe bacterial infections

How Cilastatin Works

Cilastatin acts by inhibiting the renal dehydropeptidase enzyme, which breaks down certain antibiotics like imipenem. By inhibiting this enzyme, cilastatin helps to maintain therapeutic levels of imipenem in the urine, reducing the risk of kidney damage.

Side Effects of Cilastatin

Common side effects may include nausea, vomiting, diarrhea, headache, and allergic reactions. Serious side effects can include seizures, hallucinations, and severe skin reactions. Consult a healthcare professional if any severe side effects occur.

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Cilastatin Related Warnings

Alcohol Limited Data

Limited data are available regarding the interaction of cilastatin with alcohol. Caution is advised, and it is recommended to consult with a healthcare professional before combining the two.

Pregnancy Limited Data

There is limited data on the safety of cilastatin during pregnancy. Consultation with a healthcare provider is recommended to assess potential risks and benefits.

Lactation Limited Data

Limited data are available regarding the safety of cilastatin during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.

Driving Use With Care

Caution is advised while driving or operating machinery, as cilastatin may cause dizziness or drowsiness in some individuals. It is essential to assess individual response before engaging in activities that require alertness.

Kidney Safe If Prescribed

Cilastatin is generally safe for use in individuals with normal kidney function when prescribed appropriately. However, caution is advised in patients with pre-existing kidney issues, and dosage adjustments may be necessary.

Liver Safe If Prescribed

Safe use of cilastatin has been observed when used as prescribed, with no significant liver-related concerns reported.