Flurbiprofen Oral

Information About Flurbiprofen Oral

Uses of Flurbiprofen Oral

Flurbiprofen is commonly used to treat ankylosing spondylitis, arthralgia (joint pain), dental pain, gout, headache, mouth ulcers, musculoskeletal pain, osteoarthritis, pain during menstruation, post-operative pain, rheumatic pain, and rheumatoid arthritis.

How Flurbiprofen Oral Works

Flurbiprofen inhibits the synthesis of prostaglandin by decreasing cyclooxygenase activity which then causes a reduction in prostaglandin levels. It is also a strong inhibitor of platelet aggregation.

Side Effects of Flurbiprofen Oral

Dizziness, Headache, Dyspepsia, Diarrhea, Abdominal pain, Nausea, Vomiting, Constipation, Gastrointestinal bleeding, Edema

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Flurbiprofen Oral Related Warnings

Alcohol Not Advisable

It is not advisable to drink alcohol with flurbiprofen because the alcohol may increase the risk of gastrointestinal bleeding caused by Flurbiprofen.

Pregnancy Not Safe

There is an increased risk of miscarriage, cardiac malformation, and gastroschisis following usage of prostaglandin synthesis inhibitor during early pregnancy. Animal studies have demonstrated that there is an adverse risk to the fetus and there are inadequate human studies, though potential benefits may allow the usage of Flurbiprofen in pregnant women. Flurbiprofen should be avoided during the first and second trimester of pregnancy unless it is deemed necessary, with the lowest dose possible and the shortest duration of treatment. It is contraindicated during the third trimester.

Lactation Limited Data

Flurbiprofen is excreted in human breast milk in a very small amount thus it is not recommended to be used during breastfeeding.

Driving Generally Safe

Flurbiprofen usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Non-steroidal anti-inflammatory drugs (NSAIDs) such as flurbiprofen may cause a dose-dependent reduction in the formation of prostaglandin and this will precipitate renal failure. The risk of renal failure is increased in patients with underlying impaired renal function and thus, their renal function should be monitored closely.

Liver Limited Data

Non-steroidal anti-inflammatory drugs (NSAIDs) such as flurbiprofen may cause elevation of liver function test. In those with hepatic impairment, dose adjustment may be needed as Flurbiprofen is extensively metabolised by the liver.